Dr. rer. nat. Rafael Schmid

Growth factors IGF-1, KGF and adipose-derived stem cells promote migration and viability of primary human keratinocytes in an in vitro wound model
Stadelmann N, Horch RE, Schmid R, Ostendorf D., Peddi A, Promny T, Boos AM, Kengelbach-Weigand A.
Front. Med. Sec. Translational Medicine. 2025, Volume 12 - 2025 | doi: 10.3389/fmed.2025.1516116.

Ink comparison for extrusion-based bioprinting in the context of breast cancer and melanoma models
Heltmann-Meyer S, Fleischer S, Kadam S, Boccaccini AR, Kirmsse S, Forster L, Teßmar J, Schrüfer S, Lamberger Z, Stahlhut P, Lang G, Boßerhoff AK, Arkudas A, Horch RE, Kengelbach-Weigand A, Schmid R. 
International Journal of Bioprinting. 2025, 5828. Doi: 10.36922/ijb.5828.

Disturbed spatial WNT activation – a potential driver of the reticularized skin phenotype in Systemic Sclerosis (SSc).
Chenguiti Fakhouri S, Zhu H, Li YN, Ronicke M, Rigau AR, Dees C, Konstantinidis L, Schmid R, Matei AE, Eckstein M, Geppert C, Ludolph I, Kreuter A, Sticherling M, Berking C, Horch RE, Schett G, Distler JHW and Bergmann C. 
Arthritis Rheumatol. 2024 Dec 25. doi: 10.1002/art.43094.

An alginate-cellulose based bioink mimics the viscoelastic features of the melanoma microenvironment and its influence on cell cycle and invasion
Eckert C, Schmidt SK, Faber J, Detsch R, Vielreicher M, Lamberger Z, Stahlhut P, Sandor E, Karimi T,   Schmid R, Arkudas A, Friedrich O, Budday S, Lang G, Kengelbach-Weigand A, Bosserhoff AK.
Bioprinting. 2025, Volume 46, e00384; doi: 10.1016/j.bprint.2024.e00384.

Something Old and Something New—A Pilot Study of Shrinkage and Modern Imaging Devices.
Hearing JVW, Horch RE, Schmid R, Geppert CI, Stumpfe MC. 
Life. 2025; 15(1):30. doi: 10.3390/life15010030.

The Effect of Ionizing Irradiation on the Autotaxin-Lysophasphatidic Acid Axis and Interleukin-6/8 Secretion in Different Breast Cancer Cell Lines
Promny T, Scherrer I, Kadam S, Schmid R, Jost T, Distel LV, Arkudas A, Horch RE, Kengelbach-Weigand A.
J. Pers. Med. 2024, 14(9), 968; doi: 10.3390/jpm14090968.

Bioprinted keratinocyte and stem cell-laden constructs for skin tissue engineering.
Bettendorf E*, Schmid R*, Horch RE, Kengelbach-Weigand A, Kulike Y, Schrüfer S, Schubert DW, Lamberger Z, Stahlhut P, Lang G, Sörgel CA. 
International Journal of Bioprinting. 2024, 10(6), 3925.doi: 10.36922/ijb.3925

Characterization of two different alginate-based bioinks and the influence of melanoma growth within.
Schipka R, Heltmann-Meyer S, Schneidereit D, Friedrich O, Röder J, Boccaccini AR, Schrüfer S, Schubert DW, Horch RE, Bosserhoff AK, Arkudas A, Kengelbach-Weigand A*, Schmid R*. 
Sci Rep. 2024 Jun 5;14(1):12945. doi: 10.1038/s41598-024-63642-3.

A vascularized in vivo melanoma model suitable for metastasis research of different tumor stages using fundamentally different bioinks.
Schmid R, Schmidt SK, Schrüfer S, Schubert DW, Heltmann-Meyer S, Schicht M, Paulsen F, Horch RE, Bosserhoff AK, Kengelbach-Weigand A, Arkudas A. 
Mater Today Bio. 2024 Apr 27;26:101071. doi: 10.1016/j.mtbio.2024.101071. eCollection 2024 Jun.

Perspectives on the Current State of Bioprinted Skin Substitutes for Wound Healing.
Sörgel CA, Cai A, Schmid R*, Horch RE*. 
Biomedicines. 2023 Sep 29;11(10):2678. doi: 10.3390/biomedicines11102678.

Comparison of the Behavior of 3D-Printed Endothelial Cells in Different Bioinks
Schulik J, Salehi S, Boccaccini RE, Schrüfer S, Schubert DW, Arkudas A, Kengelbach-Weigand A, Horch RE*, Schmid R*.
Bioengineering. 2023, 10(7), 751; doi: 10.3390/bioengineering10070751.

Secretome of Adipose-Derived Stem Cells Cultured in Platelet Lysate Improves Migration and Viability of Keratinocytes.
Hermann M, Peddi A, Gerhards A, Schmid R, Schmitz D, Arkudas A, Weisbach V, Horch RE, Kengelbach-Weigand A. 
Int J Mol Sci. 2023 Feb 9;24(4):3522. doi: 10.3390/ijms24043522.

Air-Pressure-Supported Application of Cultured Human Keratinocytes in a Fibrin Sealant Suspension as a Potential Clinical Tool for Large-Scale Wounds.
Sörgel CA, Schmid R, Kengelbach-Weigand A, Promny T, Horch RE.
J Clin Med. 2022 Aug 27;11(17):5032. doi: 10.3390/jcm11175032.

An In Vitro Approach for Investigating the Safety of Lipotransfer after Breast-Conserving Therapy.
Promny T, Kutz CS, Jost T, Distel LV, Kadam S, Schmid R, Arkudas A, Horch RE, Kengelbach-Weigand A. 
J Pers Med. 2022 Aug 5;12(8):1284. doi: 10.3390/jpm12081284.

Influence of the autotaxin-lysophosphatidic acid axis on cellular function and cytokine expression in different breast cancer cell lines.
Hauck T, Kadam S, Heinz K, Garcia Peraza M, Schmid R, Kremer AE, Wolf K, Bauer A, Horch RE, Arkudas A, Kengelbach-Weigand A. 
Sci Rep. 2022 Apr 1;12(1):5565. doi: 10.1038/s41598-022-09565-3.

Role of Fiber Thickness and Surface Treatment of Electrospun Polycaprolactone Matrices on the Growth of Different Breast Cancer-Associated Cells
Sivakumar S, Schmid R, Wieland A, Strissel PL, Strick R, Fischer L, Thievessen I, Kataev E, Arkudas A, Horch RE, Schubert DW, Kengelbach-Weigand A. 
Advanced Material Interfaces. 2022 Feb 7; 2101808. doi: 10.1002/admi.202101808.

IGF-I and Hyaluronic Acid Mitigate the Negative Effect of Irradiation on Human Skin Keratinocytes.
Sörgel CA, Schmid R, Stadelmann N, Weisbach V, Distel L, Horch RE, Kengelbach-Weigand A. 
Cancers (Basel). 2022 Jan 24;14(3):588. doi: 10.3390/cancers14030588.

A New Printable Alginate/Hyaluronic Acid/Gelatin Hydrogel Suitable for Biofabrication of In Vitro and In Vivo Metastatic Melanoma Models
Schmid R, Schmidt SK, Detsch R, Horder H, Blunk T, Schrüfer S, Schubert DW, Fischer L, Thievessen I, Heltmann-Meyer S, Steiner D, Schneidereit D, Friedrich O, Grüneboom A, Amouei H, Wajant H, Horch RE, Bosserhoff AK, Arkudas A, Kengelbach-Weigand A.
Advanced Functional Materials. 2021 Oct 13;2107993. doi: 10.1002/adfm.202107993.

Molecular Changes Induced in Melanoma by Cell Culturing in 3D Alginate Hydrogels
Kappelmann-Fenzl M, Schmidt SK, Fischer S, Schmid R, Lämmerhirt L, Fischer L, Schrüfer S, Thievessen I, Schubert DW, Matthies A, Detsch R, Boccaccini AR, Arkudas A, Kengelbach-Weigand A, Bosserhoff AK. 
Cancers (Basel). 2021 Aug 15;13(16):4111. doi: 10.3390/cancers13164111.

Comparison of Hydrogels for the Development of Well-Defined 3D Cancer Models of Breast Cancer and Melanoma
Schmid R, Schmidt SK, Hazur J, Detsch R, Maurer E, Boccaccini AR, Hauptstein J, Teßmar J, Blunk T, Schrüfer S, Schubert DW, Horch RE, Bosserhoff AK, Arkudas A, Kengelbach-Weigand A. 
Cancers (Basel). 2020 Aug 17;12(8):2320. doi: 10.3390/cancers12082320.

Size matters-in vitro behaviour of human fibroblasts on textured silicone surfaces with different pore sizes
Tolksdorf J, Horch RE, Grüner JS, Schmid R, Kengelbach-Weigand A, Schubert DW, Werner S, Schneidereit D, Friedrich O, Ludolph I. 
J Mater Sci Mater Med. 2020 Feb 3;31(2):23. doi: 10.1007/s10856-020-6360-5.

Tumor Cells Develop Defined Cellular Phenotypes After 3D-Bioprinting in Different Bioinks
Schmidt SK, Schmid R, Arkudas A, Kengelbach-Weigand A, Bosserhoff AK. 
Cells. 2019 Oct 22;8(10):1295. doi: 10.3390/cells8101295.

Plasticity of patient-matched normal mammary epithelial cells is dependent on autologous adipose-derived stem cells
Kengelbach-Weigand A, Tasbihi K, Strissel PL, Schmid R, Marques JM, Beier JP, Beckmann MW, Strick R, Horch RE, Boos AM.
Sci Rep. 2019 Jul 24;9(1):10722. doi: 10.1038/s41598-019-47224-2.

Tumor‑type‑dependent effects on the angiogenic abilities of endothelial cells in an in vitro rat cell model
Al-Abboodi M, An R, Weber M, Schmid R, Klausing A, Horch RE, Boos AM, Kengelbach-Weigand A.
Oncol Rep. 2019 Jul;42(1):350-360. doi: 10.3892/or.2019.7143. Epub 2019 May 2.

Intra- and Postoperative Blood Flow Monitoring in a Sheep Model of Uterus Transplantation
Kengelbach-Weigand A, Lotz L, Schmid R, Lang W, Beckmann MW, Hoffmann I, Horch RE, Renner SP, Dittrich R, Boos AM, Hildebrandt T.
In Vivo. 2019 Mar-Apr;33(2):325-336. doi: 10.21873/invivo.11478.

ADSCs and adipocytes are the main producers in the autotaxin-lysophosphatidic acid axis of breast cancer and healthy mammary tissue in vitro
Schmid R*, Wolf K*, Robering JW, Strauß S, Strissel PL, Strick R, Rübner M, Fasching PA, Horch RE, Kremer AE, Boos AM, Weigand A.
BMC Cancer. 2018 Dec 19;18(1):1273. doi: 10.1186/s12885-018-5166-z.
Myogenic differentiation of primary myoblasts and mesenchymal stromal cells under serum-free conditions on PCL-collagen I-nanoscaffolds
Cai A, Hardt M, Schneider P, Schmid R, Lange C, Dippold D, Schubert DW, Boos AM, Weigand A, Arkudas A, Horch RE, Beier JP.
BMC Biotechnol. 2018 Nov 26;18(1):75. doi: 10.1186/s12896-018-0482-6.

Proangiogenic effects of tumor cells on endothelial progenitor cells vary with tumor type in an in vitro and in vivo rat model
An R, Schmid R, Klausing A, Robering JW, Weber M, Bäuerle T, Detsch R, Boccaccini AR, Horch RE, Boos AM, Weigand A.
FASEB J. 2018 Oct;32(10):5587-5601. doi: 10.1096/fj.201800135RR. Epub 2018 May 10.

Bone Tissue Engineering Under Xenogeneic-Free Conditions in a Large Animal Model as a Basis for Early Clinical Applicability
Weigand A, Beier JP, Schmid R, Knorr T, Kilian D, Götzl R, Gerber T, Horch RE, Boos AM.
Tissue Eng Part A. 2017 Mar;23(5-6):208-222. doi: 10.1089/ten.TEA.2016.0176. Epub 2017 Jan 30.